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Furosemide 50 mg, 100 Tablets satisfaction Gauranteed

Intervet, Inc. Item# 1010450 | Availability: Back Order

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    Furosemide is an effective diuretic that promotes the rapid removal of abnormally retained extracellular fluids.

    Description

    FUROSEMIDE TABLETS

    A DIURETIC-SALURETIC FOR PROMPT RELIEF OF EDEMA

    NADA 129-034, Approved by FDA

    FOR USE IN DOGS ONLY

    Furosemide Tablets are not USP for dissolution.

    CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

    DESCRIPTION: Furosemide is a potent loop diuretic which is a derivative of anthranilic acid. The structure is:

    Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranillic acid. Furosemide is pharmaco-dynamically characterized by the following:

    1) It is administered orally. It is easily absorbed from the intestinal tract and begins to act in 30 to 60 minutes after oral administration.1 2

    2) Is a loop diuretic which inhibits reabsorption of sodium and chloride at the ascending loop of Henle in the kidneys, enhancing water excretion.3

    3) A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold.1

    4) A high degree of efficacy, low inherent toxicity and a high therapeutic index.

    ACTIONS: The therapeutic efficacy of Furosemide Tablets is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule but also in the ascending limb of the loop of Henle. The prompt onset of action is a result of the drug's rapid absorption and a poor lipid solubility. The low lipid solubility and a rapid renal excretion minimize the possibility of its accumulation in tissues and organs or crystalluria. Furosemide Tablets have no inhibitory effect on carbonic anhydrase or aldosterone activity in the distal tubule. The drug possesses diuretic activity either in the presence of acidosis or alkalosis.1 2 4 5 6

    INDICATIONS: DOGS - Furosemide Tablets are indicated for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema. In cases of edema involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated. The rationale for efficacious use of diuretic therapy is determined by the clinical pathology producing the edema.

    CONTRAINDICATIONS: Animal reproductive studies have shown that furosemide may cause fetal abnormality and the drug is contraindicated in pregnant animals. Furosemide is contraindicated in anuria, furosemide hypersensitivity, hepatic coma, or during electrolytic imbalances. Monitor serum electrolytes, BUN and CO2 frequently. Monitor serum potassium levels and watch for signs of hypocalcemia.

    Corticosteroids cause an additive potassium-depletion effect.

    PRECAUTIONS: Furosemide Tablets are a highly effective diuretic-saluretic which, if given in excessive amounts, may result in dehydration and electrolyte imbalance. Therefore, the dosage and schedule may have to be adjusted to the patient's need. The animal should be observed for early signs of electrolyte imbalance, and corrective measures administered. Early signs of electrolyte imbalance are increased thirst, lethargy, drowsiness or restlessness, fatigue, oliguria, gastro-intestinal disturbances and tachycardia. Special attention should be given to potassium levels. Furosemide Tablets may lower serum calcium levels and cause tetany in rare cases of animals having an existing hypocalcemic tendency.7 8 9 10 11

    Furosemide Tablets are contraindicated in anuria. Therapy should be discontinued in cases of progressive renal disease if increasing azotemia and oliguria occur during the treatment. Sudden alterations of fluid and electrolyte imbalance in an animal with cirrhosis may precipitate hepatic coma, therefore, observation during period of therapy is necessary. In hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved or corrected. Potassium supplementation may be necessary in cases routinely treated with potassium-depleting steroids.

    Active or latent diabetes may on rare occasions be exacerbated by furosemide. Transient loss of auditory capacity has been experimentally produced in cats following intravenous injections of excessive doses of furosemide at a very rapid rate.12 13 14

    WARNINGS: Furosemide Tablets are a highly effective diuretic and, if given in excessive amounts, as with any diuretic, may lead to excessive diuresis which could result in electrolyte imbalance, dehydration and reduction of plasma volume, enhancing the risk of circulatory collapse, thrombosis and embolism. Therefore, the animal should be observed for early signs of fluid depletion with electrolyte imbalance, and corrective measures administered. Excessive loss of potassium in patients receiving digitalis or its glycosides may precipitate digitalis toxicity. Caution should be exercised in animals administered potassium-depleting steroids. Correct potassium deficiency with proper dietary supplementation. If animal needs potassium supplements, use oral liquid form, do not use enteric-coated potassium tablets.

    The concurrent use of furosemide with some antibiotics may be inadvisable. There is evidence that the drug enhances the nephrotoxic potential of aminoglycosides, cephalosporins and polymyxins and increases the ototoxic effects of aminoglycosides.

    Sulfonamide diuretics have been reported to decrease arterial responsiveness to pressor amines and to enhance the effect of tubocurarine. Caution should be exercised in administering curare or its derivatives to patients undergoing therapy with Furosemide Tablets and it is advisable to discontinue Furosemide Tablets for one day prior to any elective surgery.

    NOT FOR ANIMALS INTENDED FOR FOOD.

    DOSAGE AND ADMINISTRATION: The usual dosage of Furosemide Tablets is 1 to 2 mg/lb body weight (approximately 2.5 to 5 mg/kg). A prompt diuresis usually ensues from the initial treatment.

    Administer orally once or twice daily at 6 to 8 hour intervals. The dosage should be adjusted to the individual's response. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 1.0 mg per pound of body weight. The established effective dose should be administered once or twice daily. The daily schedule of administration can be timed to control the period of micturition for the convenience of the client or veterinarian. Mobilization of the edema may be most efficiently and safely accomplished by utilizing an intermittent daily dose schedule, i.e., every other day or 2 to 4 consecutive days weekly.

    Diuretic therapy should be discontinued after reduction of the edema, or maintained after determining a carefully programmed dosage schedule to prevent recurrence of edema. For long-term treatment, the dose can generally be lowered after the edema has once been reduced. Re-examination and consultations with the client will enhance the establishment of a satisfactorily programmed dosage schedule. Clinical examination and serum BUN, CO2 and electrolyte determinations should be performed during the early period of therapy and periodically thereafter, especially in refractory cases. Abnormalities should be corrected or the drug temporarily withdrawn.

    DOSAGE: ORAL

    DOG: One-half to one 50 mg scored tablet per 25 pounds body weight. One 12.5 mg scored tablet per 5 to 10 pounds body weight.

    Administer once or twice daily, permitting a 6- to 8-hour interval between treatments. In refractory or severe edematous cases, the dosage may be doubled or increased by increments of 1 mg per pound body weight as recommended in preceding paragraphs, “Dosage and Administration”.

    HOW SUPPLIED: Oral: Tablets

    12.5 mg Tablets - Each tablet contains 12.5 mg of furosemide

    50 mg Tablets - Each tablet contains 50 mg of furosemide

    Available in bottles of 500 tablets

    TOXICOLOGY: Furosemide demonstrates a very low order of either acute or chronic toxicity. The drug is rapidly absorbed and excreted by both glomerular filtration and tubular secretion. The rates of excretion are of such magnitude that cumulation of furosemide does not occur despite repeated administrations.15

    The main effect observed in clinical toxicity is an abnormality of fluid and electrolyte imbalances. Ototoxicity resulting in transient loss of hearing has been reported with furosemide.15

    A safety study was performed in dogs to determine the effects of Furosemide Tablets at increasing dosages and time elements. The dosage levels were 2 mg/lb body weight (upper recommended dosage), 6 mg/lb body weight (3X upper recommended dosage) and 10 mg/lb body weight (5X upper recommended dosage). The treatment period ranged up to nine days in length. Results demonstrate a mild dehydration at the 5X level with a slight elevation of hemoglobin and hematocrit levels. Serum levels of potassium and chloride were slightly lowered in the higher dosage groups. Cumulative evaluation of the data demonstrates that Furosemide Tablets are safe when administered at the upper level of the recommended dosage for a duration of nine consecutive days.

    NOTE: Store at controlled room temperature (59°-86°F).

    KEEP OUT OF REACH OF CHILDREN

    REFERENCES:

    1. Timmerman, R.J., F.R. Springman and R.K. Thoms, 1964. Evaluation of Furosemide, a New Diuretic Agent. Current Therapeutic Research, 6(2):88-94.

    2. Martindale, The Extra Pharmacopoeia. 27th ed. June 1977, The Pharmaceutical Press, London, 556.

    3. Suki, W., F.C. Rector, Jr. and D.W. Seldin, 1965. The Site of Action of Furosemide and Other Sulfonamide Diuretics in the Dog. Journal of Clinical Investigation, 44(9):1458-1469.

    4. Berman, L.B. and A. Ebrahimi. February 1965. Experiences with Furosemide in Renal Disease. Proceedings in the Society for Experimental Biology and Medicine, 118:333-336.

    5. Schmidt, H.A.E. Animal Experiments with S35 Tagged Lasix® in Canine and Ovine. Radio-chemical Pharmacological Laboratory, Farbwerke Hoechst, Frankfurt, West Germany.

    6. Haussler, A. and P. Hajdu. Methods Biological Identification and Results of Studies on Absorption, Elimination and Metabolism. Research Laboratories, Farbwerke Hoechst, Frankfurt, West Germany.

    7. Antoniou, L.D., G.M. Eisner, L.M. Slotkoff and L.S. Lilienfield. December 1967. Sodium and Calcium Transport in the Kidney. Clinical Research, 15(4):476.

    8. Duarte, C.G. April 1967. Effects of Furosemide (F) and Ethacrynic Acid (ETA) on the Renal Clearance of Phosphate (Cp), Ultrafilterable Calcium (CUfCa) and Magnesium (CUfMg). Clinical Research, 15(2):357.

    9. Duarte, C.G. October 1968. Effects of Ethacrynic Acid and Furosemide on Urinary Calcium, Phosphate and Magnesium. Metabolism, 17:867-876.

    10. Nielsen, S.P., O. Andersen and K.E. Steven, 1969. Magnesium and Calcium Metabolism during Prolonged Furosemide (Lasix®) Administration to Normal Rats. Acta Pharmacol, et. Toxicol., 27:469-479.

    11. Reimold, E.W. July 1972. The Effect of Furosemide on Hypercalcemia Due to Dihydrotachysterol, Metabolism, 21(7).

    12. Brown, R.D. and T.W. McElwee, Jr. Effects of Intra-Arterially and Intravenously Administered Ethacrynic Acid and Furosemide on Cochlear N1 in Cats. Toxicology and Applied Pharmacology, 22:589-594, 1972.

    13. Mathog, R.H., W.G. Thomas and W.R. Hudson. Ototoxicity of New and Potent Diuretics. Archives of Otolaryngology, 92(1):7-13, July 1970.

    14. Mathog, R.H. and G.J. Matz. Ototoxic Effects of Ethacrynic Acid. Annals of Otolaryngology, Vol. 81, 1972.

    15. Gilman, A.G., L.S. Goodman and A. Gilman, 1980. The Pharmacological Basis of Therapeutics, Sixth ed., MacMillan Publishing Co., Inc., New York, NY, 903-907.

    Distributed by: VEDCO, INC., St. Joseph, MO 64507

     

    NET CONTENTS:

    NDC

     

    12.5 mg

    500 TABLETS

    50989-389-52

    673833L-00-0407

    50 mg

    500 TABLETS

    50989-269-52

    673933L-00-0407

    NAC No.: 10940980

    Reviews

    Product Reviews
    Overall Customer Rating:
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    Customer Reviews: 4
    a lifesaver
    Rating:
    review-star review-star review-star review-star review-star
    Author:
    esl
    Location:
    va
    Review Date:
    10/14/2011

    Pros:
    Cons:
    This product works great. I am on my second chessie who has degenerative heart disease and this with enapril helps my kate be free from the coughing and other symptons. My first chessie doc lived 1 1/2 years on this medicine. Also VetDepot is the least expensive which helps when having to order so much.
    Furosemide
    Rating:
    review-star review-star review-star review-star review-star
    Author:
    Dan
    Location:
    Review Date:
    2/8/2011

    Pros:
    Cons:
    This medicine is being taken by a 12 year old Lab named Jake. The vet diagnosed him with congestive heart failure. The medicine has improved Jake's quality of life, this is evident by improved energy/mobility and reduced coughing and breathing issues.
    Great value!
    Rating:
    review-star review-star review-star review-star review-star
    Author:
    fillyok
    Location:
    Review Date:
    11/10/2010

    Pros:
    Cons:
    I do Chow Chow rescue in South Texas and we run into problems with our rescues being HW+ a lot. One particular Chow Chow, Layla, was found stranded in a lake. She was blind and very positive for HWs. It's hard to determine her age since she was neglected for many years, but we guess 8/9 years old. She's been diagnosed with heart failure and was prescribed furosemide. The vet prices are extremely high, but luckily my vet will write prescriptions for me and I can get them filled on-line. I'd printed out vetdepot's prices for the meds I needed and even she was surprised at the great deal I could get. I'll be ordering soon again.

    Now Layla is back to her spunky self and living out her life in comfort. Thank goodness for vetdepot!!
    Furosemide 50 mg, 100 Tablets
    Rating:
    review-star review-star review-star review-star review-star
    Author:
    ellen
    Location:
    Review Date:
    11/9/2010

    Pros:
    Cons:
    my dog has congestive heart failure and furosemide with enaparil have extended his life expectancy so far by 6 months. he no longer coughs and even though he has to urinate a lot it is well worth it.

    This information is for general reference only and should not be used for the diagnosis or treatment of any condition of your pet. Because is intended as a general reference, this information may not include all possible uses, precautions, directions, reactions (including allergic), drug interactions, or withdrawal times. Always consult your local veterinarian and have your pet examined for any advice concerning the diagnosis and treatment of your pet, including which products and doses are most appropriate. Any trademarks are the property of their respective owners. VetDepot is not a pharmacy. All prescription products are dispensed by our Pharmacy Partner.

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